THE LXR-IDOL AXIS DEFINES A CLATHRIN-, CAVEOLAE-, AND DYNAMIN-INDEPENDENT ENDOCYTIC ROUTE FOR LDLR INTERNALIZATION AND LYSOSOMAL DEGRADATION

The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

Low density lipoprotein (LDL) cholesterol is taken up into cells via clathrin-mediated endocytosis of the LDL receptor (LDLR).Following dissociation of the LDLR-LDL complex, LDL is directed to lysosomes whereas the LDLR recycles to the plasma membrane.Activation of the sterol-sensing nuclear receptors liver X receptors (LXRs) enhances degradation o

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Streamlining the Small Claims Procedure in North Macedonia: How Far are we from Digitalisation at National and European Cross- Border Level?

The streamlining of Men’s Teeshirt small claims procedures has preoccupied national and European legislators for some time.Unfortunately, what is happening at the European level and beyond, until recently did not find an echo in the Macedonian small claims procedure The paper will demonstrate that the overall direction of the changes in this proc

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